RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
Mir29b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; immunohistofluorescence; etc.
Target
COLLAGEN I; COLLAGEN IV; C-MYC; PDGF-B; PI3K; AKT
Pathway
NA
PubMed ID
Title
Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liverf ibrosis
Year
2015
Function
"Mir-29b1 targets several fibrotic genes such as type i and type iv collagen, c-myc, pdgf-b and pi3k ; Akt, inhibit hh pathway and overexpression of mir-29b1 synergistic effect to reduce liver injury-related serum enzyme levels, reduce collagen deposition."